Clinical and Interpretive:

This test is used in the diagnosis of Hepatitis A infection.

Hepatitis A virus (HAV) is a cause of morbidity and socio-economic loss in many parts of the world. Transmission is typically via the fecal-oral route associated with contaminated water or food. In areas where sanitation is poor, infections often occur early in life.  In childhood, HAV infection is generally mild or asymptomatic and results in lifelong immunity.  With improved sanitation and hygiene, infections are delayed, and consequently the number of adolescents and adults susceptible to the virus increases.  In adolescents and adults, HAV is more serious leading to hepatitis and an increased mortality rate.

Anti-HAV IgM is detectable during the acute stage of the illness, while anti-HAV IgG may be present for many years after recovery or following vaccination.  The presence of anti-HAV (IgG or IgM) in human serum or plasma is indicative of past or present infection with HAV or vaccination against HAV.  The test for Total Anti-HAV is primarily used to determine exposure to HAV either naturally or due to vaccination.