Interpretive Data

Because each patient is regarded as unique in the handling of this potent immunosuppressive agent, there is no standard reference range for Cyclosporine A. The complexity of the clinical state, individual differences in sensitivity to the immunosuppressive and nephrotoxic effects of CsA, the co-administration of other  immunosuppressant, the type of transplant, time post-transplant and a number of other factors will cause different requirements for optimal whole blood level of CsA. Individual whole blood CsA cannot be used as the sole indicator for making changes in the treatment regimen. Each patient should be thoroughly evaluated clinically before treatment adjustments are made and each user must establish his/her own ranges based on these clinical experiences.